Research Progress on NSP11 of Porcine Reproductive and Respiratory Syndrome Virus

Porcine reproductive and respiratory syndrome (PRRS) is a virulent infectious disease caused by the PRRS virus (PRRSV). The non-structural protein 11 (NSP11) of PRRSV nidovirus-specific endonuclease (NendoU), which displays uridine specificity catalytic functions conserved throughout entire NendoU family exerts wide range biological effects. This review discusses genetic evolution NSP11, its effects on replication virulence, interaction with other host proteins, regulation immunity, characteristics enzyme activity diagnosis, providing an essential theoretical basis for in-depth studies pathogenesis vaccine design.